On thе bаsis оf аnаlyzing thе dеvеlоpmеnt оf Viеtnаmеsе philоsоphiсаl thоught in thе еаrly twеntiеth сеntury, thе аuthоr mаkеs sоmе bаsiс оbsеrvаtiоns аs fоllоws: firstly, Viеtnаmеsе philоsоphiсаl thоught in thе еаrly twеntiеth сеntury is gоvеrnеd by histоriсаl-spесifiс mаtеriаl аnd sосiаl соnditiоns; sесоnd, thе rесеptiоn оf Mаrxist-Lеninist philоsоphy is оf spесiаl impоrtаnсе; third, thе dеvеlоpmеnt оf nаtiоnаl philоsоphiсаl thоught аt this stаgе is а prосеss оf diаlесtiсаl ассulturаtiоn; fоurth, thе mаin соntеnt оf Viеtnаmеsе philоsоphiсаl thоught in thе еаrly twеntiеth сеntury is (...) thе issuе оf nаtiоnаl indеpеndеnсе аnd sосiаl dеmосrасy; fifth, its еxprеssiоn fоrm is synthеtiс. (shrink)

On thе bаsis оf аnаlyzing thе dеvеlоpmеnt оf Viеtnаmеsе philоsоphiсаl thоught in thе еаrly twеntiеth сеntury, thе аuthоr mаkеs sоmе bаsiс оbsеrvаtiоns аs fоllоws: firstly, Viеtnаmеsе philоsоphiсаl thоught in thе еаrly twеntiеth сеntury is gоvеrnеd by histоriсаl-spесifiс mаtеriаl аnd sосiаl соnditiоns; sесоnd, thе rесеptiоn оf Mаrxist-Lеninist philоsоphy is оf spесiаl impоrtаnсе; third, thе dеvеlоpmеnt оf nаtiоnаl philоsоphiсаl thоught аt this stаgе is а prосеss оf diаlесtiсаl ассulturаtiоn; fоurth, thе mаin соntеnt оf Viеtnаmеsе philоsоphiсаl thоught in thе еаrly twеntiеth сеntury is (...) thе issuе оf nаtiоnаl indеpеndеnсе аnd sосiаl dеmосrасy; fifth, its еxprеssiоn fоrm is synthеtiс. (shrink)

The relation of ontological dependence or grounding, expressed by the terminology of separation and priority in substance, plays a central role in Aristotle’s Categories, Metaphysics, De Anima and elsewhere. The article discusses three current interpretations of this terminology. These are drawn along the lines of, respectively, modal-existential ontological dependence, essential ontological dependence, and grounding or metaphysical explanation. I provide an opinionated introduction to the topic, raising the main interpretative questions, laying out a few of the exegetical and philosophical options that (...) influence one’s reading, and locating questions of Aristotle scholarship within the discussion of ontological dependence and grounding in contemporary metaphysics. (shrink)

Both literalism, the view that mathematical objects simply exist in the empirical world, and fictionalism, the view that mathematical objects do not exist but are rather harmless fictions, have been both ascribed to Aristotle. The ascription of literalism to Aristotle, however, commits Aristotle to the unattractive view that mathematics studies but a small fragment of the physical world; and there is evidence that Aristotle would deny the literalist position that mathematical objects are perceivable. The ascription of fictionalism also faces a (...) difficult challenge: there is evidence that Aristotle would deny the fictionalist position that mathematics is false. I argue that, in Aristotle's view, the fiction of mathematics is not to treat what does not exist as if existing but to treat mathematical objects with an ontological status they lack. This form of fictionalism is consistent with holding that mathematics is true. (shrink)

A predicate logic typically has a heterogeneous semantic theory. Subjects and predicates have distinct semantic roles: subjects refer; predicates characterize. A sentence expresses a truth if the object to which the subject refers is correctly characterized by the predicate. Traditional term logic, by contrast, has a homogeneous theory: both subjects and predicates refer; and a sentence is true if the subject and predicate name one and the same thing. In this paper, I will examine evidence for ascribing to Aristotle the (...) view that subjects and predicates refer. If this is correct, then it seems that Aristotle, like the traditional term logician, problematically conflates predication and identity claims. I will argue that we can ascribe to Aristotle the view that both subjects and predicates refer, while holding that he would deny that a sentence is true just in case the subject and predicate name one and the same thing. In particular, I will argue that Aristotle's core semantic notion is not identity but the weaker relation of constitution. For example, the predication ‘All men are mortal’ expresses a true thought, in Aristotle's view, just in case the mereological sum of humans is a part of the mereological sum of mortals. (shrink)

The expression tode ti, commonly translated as ‘a this’, plays a key role in Aristotle’s metaphysics. Drawing lightly on theories of demonstratives in contemporary linguistics, I discuss the expres...

Aristotle holds that individual substances are ontologically independent from nonsubstances and universal substances but that non-substances and universal substances are ontologically dependent on substances. There is then an asymmetry between individual substances and other kinds of beings with respect to ontological dependence. Under what could plausibly be called the standard interpretation, the ontological independence ascribed to individual substances and denied of non-substances and universal substances is a capacity for independent existence. There is, however, a tension between this interpretation and the (...) asymmetry between individual substances and the other kinds of entities with respect to ontological independence. I will propose an alternative interpretation: to weaken the relevant notion of ontological independence from a capacity for independent existence to the independent possession of a certain ontological status. (shrink)

Is there grounding in ancient philosophy? To ask a related but different question: is grounding a useful tool for the scholar of ancient philosophy? These questions are difficult, and my goal in this paper is not so much to give definitive answers as to clarify the questions. I hope to direct the student of contemporary metaphysics towards passages where it may be fruitful to look for historical precedent. But I also hope to offer the student of ancient philosophy some guidance (...) on when drawing on the contemporary discussion of grounding may be beneficial. (shrink)

Discussion of the Aristotelian syllogistic over the last sixty years has arguably centered on the question whether syllogisms are inferences or implications. But the significance of this debate at times has been taken to concern whether the syllogistic is a logic or a theory, and how it ought to be represented by modern systems. Largely missing from this discussion has been a study of the few passages in the Prior Analytics where Aristotle provides explicit guidance on how to individuate syllogisms. (...) I argue that syllogisms are individuated by unordered premise pairs and so may be fruitfully thought of as multi-succedent sequents. I conclude by drawing a few consequences for the representation of the syllogistic. (shrink)

As a first stab, call a property recurrent if it can be possessed by more than one object, and nonrecurrent if it can be possessed by at most one object. The question whether Aristotle holds that there are nonrecurrent properties has spawned a lively and ongoing debate among commentators over the last forty-five years. One source of textual evidence in the Categories, drawn on in this debate, is Aristotle’s claim that certain properties are inseparable from what they are in. Here (...) the point of contention is whether this commits Aristotle to holding that these properties are inseparable from individuals, since it is commonly held that a property is nonrecurrent, if it is inseparable from an individual. I argue that this evidence is neutral on the question whether there are nonrecurrent properties in Aristotle. One of my aims here is to disentangle the question of recurrence from local issues of individuality and universality in the Categories. But another aim is to turn from the textual considerations, which have dominated the debate, to broader methodological considerations. It is a shared assumption among all those who look to textual evidence from the Categories, so to decide whether Aristotle believes there are nonrecurrent properties, that in this work Aristotle is engaged in a project where the question of recurrence is relevant. I argue that Aristotle’s concerns in the Categories are disjoint from the question of recurrence, and so this shared assumption is false. (shrink)

Although arguments for and against competing theories of vagueness often appeal to claims about the use of vague predicates by ordinary speakers, such claims are rarely tested. An exception is Bonini et al. (1999), who report empirical results on the use of vague predicates by Italian speakers, and take the results to count in favor of epistemicism. Yet several methodological difficulties mar their experiments; we outline these problems and devise revised experiments that do not show the same results. We then (...) describe three additional empirical studies that investigate further claims in the literature on vagueness: the hypothesis that speakers confuse ‘P’ with ‘definitely P’, the relative persuasiveness of different formulations of the inductive premise of the Sorites, and the interaction of vague predicates with three different forms of negation. (shrink)

Aristotle draws what are, by our lights, two unusual relationships between predication and existence. First, true universal affirmations carry existential import. If ‘All humans are mortal’ is true, for example, then at least one human exists. And secondly, although affirmations with empty terms in subject position are all false, empty negations are all true: if ‘Socrates’ lacks a referent, then both ‘Socrates is well’ and ‘Socrates is ill’ are false but both ‘Socrates is not well’ and ‘Socrates is not ill’ (...) are true. In this paper, I conjecture that for Aristotle predications have mereological truth conditions: for example, ‘Socrates is pale’ is true just in case Socrates is a part of the mereological sum of pale things. The existential import of universal affirmations and the semantic profile of empty negations follow from this mereological semantics. (shrink)

Causal pluralists hold that that there is not just one determinate kind of causation. Some causal pluralists hold that ‘cause’ is ambiguous among these different kinds. For example, Hall (2004) argues that ‘cause’ is ambiguous between two causal relations, which he labels dependence and production. The view that ‘cause’ is ambiguous, however, wrongly predicts zeugmatic conjunction reduction, and wrongly predicts the behaviour of ellipsis in causal discourse. So ‘cause’ is not ambiguous. If we are to disentangle causal pluralism from the (...) ambiguity claim, we need to consider what other linguistic approaches are available to the causal pluralist. I consider and reject proposals that ‘cause’ is a general term, that the term is an indexical, and that the term conveys different kinds of causation through implicature or presupposition. Finally, I argue that causal pluralism is better handled by treating ‘cause’ as a univocal term within a dynamic interpretation framework. (shrink)

In the first part of the paper, I’ll rehearse an argument that perceiving that we see and hear isn’t a special case of perception in Aristotle but is rather a necessary condition for any perception whatsoever: the turning of one’s attention to the affection of the sense organs. In the second part of the paper, I’ll consider the thesis that the activity of the active intellect is analogous to perceiving that we see and hear.

When Aristotle introduces the perfect moods, he refers back to the dictum de omni et nullo, a semantic condition for universal affirmations and negations. There recently has been renewed interest in the question whether the dictum validates the assertoric syllogistic. I rehearse evidence that Aristotle provides a mereological semantics for universal affirmations and negations, and note that this semantics entails a nonstandard reading of the dictum, under which the dictum, in the presence of a minimal logical apparatus, indeed validates the (...) assertoric syllogistic. I argue that this mereological validation offers advantages over recent discussions in Morison, Malink, Ebert and Vlasits. (shrink)

Despite much discussion over the existence of moral facts, metaethicists have largely ignored the related question of their possibility. This paper addresses the issue from the moral error theorist’s perspective, and shows how the arguments that error theorists have produced against the existence of moral facts at this world, if sound, also show that moral facts are impossible, at least at worlds non-morally identical to our own and, on some versions of the error theory, at any world. So error theorists’ (...) arguments warrant a stronger conclusion than has previously been noticed. This may appear to make them vulnerable to counterarguments that take the possibility of moral facts as a premise. However, I show that any such arguments would be question-begging. (shrink)

Metaphysical explanations, unlike many other kinds of explanation, are standardly thought to be insensitive to our epistemic situation and so are not evaluable by cognitive values such as salience. I consider a case study that challenges this view. Some properties are distributed over an extension. For example, the property of being polka-dotted red on white, when instantiated, is distributed over a surface. Similar properties have been put to work in a variety of explanatory tasks in recent metaphysics, including: providing an (...) analysis of change, giving to presentists truthmakers for past claims; giving to priority monists an account of basic heterogeneous entities; and giving to friends of extended simples an explanation of how an extended simple can enjoy qualitative variation. I argue that such explanations exhibit salience failure. How ought we represent the semantics of salience? Differences in linguistic stress induce semantic differences similar to the semantic differences induced in explanations by differences in salience, and I will draw an analogy with linguistic theories of focus sensitivity to sketch how one might model the role of salience in these kinds of explanations. I end with a few tentative conclusions about the role of cognitive values in metaphysical explanations. Some theorists view the citation of a ground as a sufficient explanation. If certain explanations appealing to distributed properties exhibit attenuated salience, then arguably the mere citation of a ground does not always provide an adequate explanation. (shrink)

Presentists face a challenge from truthmaker theory: if you hold both that the only existing objects are presently existing and that truth supervenes on being, then you will be hard pressed to identify some existent on which a given true but traceless claim about the past supervenes. One reconciliation strategy, advocated by Cameron (2011), is to appeal to distributional properties so to serve as presently existing truthmakers for past truths. I argue that a presentist ought to deny that distributional properties (...) can serve as truthmakers. (shrink)

It is standardly held that Aristotle denies that artifacts are substances. There is no consensus on why this is so, and proposals include taking artifacts to lack autonomy, to be merely accidental unities, and to be impermanent. In this paper, I argue that Aristotle holds that artifacts are substances. However, where natural substances are absolutely fundamental, artifacts are merely relatively fundamental—like any substance, an artifact can ground such nonsubstances as its qualities; but artifacts are themselves partly grounded in natural substances. (...) Many contemporary metaphysicians view authorial intentions or communal recognition as an essential feature of most artifactual kinds. Drawing on Aristotle’s own examples of artifactual definitions, I note that there is little reason to ascribe this view to Aristotle. So Aristotle has the resources to hold that it is possible that there are kinds with both artifactual and non-artifactual members. (shrink)

Recent authors hold that the role of historical scholarship within contemporary philosophical practice is to question current assumptions, to expose vestiges or to calibrate intuitions. On these views, historical scholarship is dispensable, since these roles can be achieved by nonhistorical methods. And the value of historical scholarship is contingent, since the need for the role depends on the presence of questionable assumptions, vestiges or comparable intuitions. In this paper I draw an analogy between scientific and philosophical practice, in order to (...) float one role for historical scholarship that is nonreplicable and noncontingent. It has long been acknowledged that cognitive values – features of theories that facilitate understanding, such as ontological parsimony, ideological simplicity, computational ease and fecundity – play a key role within science. The role of some of these values within philosophy also has received attention but left understudied are the values of novelty and conservativeness. These values influence theory choice, the selection of methodology, the setting of research agenda, and the presentation of results; and are best assessed with a historically informed evaluation. This role for historical scholarship is not replicable by nonhistorical methods, and is not contingent on the presence of questionable assumptions, vestiges or comparable intuitions. (shrink)

I discuss Peramatzis's (2011) argument that the form of a natural substance is essentially enmattered and so contains a material component.

1 Context The idea for the current issue of _Philosophia Scientiæ_ emerged from discussions which took place in the Manchester Ethnomethodology Reading Group. This reading group has its origins in Wes Sharrock’s weekly discussion groups, which have taken place in Manchester (UK) since the early 1970s. As the global Covid-19 pandemic hit in early 2020, the reading group moved online, facilitated by Phil Hutchinson and Alex Holder. Being an online reading group opened up participation to people beyond Northwest UK (...) and within weeks the group became global, with the membership including participants logging on from Canada, Czech Republic, Finland, France, Germany, Greece, Hong Kong, Japan, Macau, New Zealand, Spain, Sweden, and the USA. While the name of the group might indicate an exclusive focus on ethnomethodology, following the naming conventions for academic discussion groups, the name really fails to indicate both the heterogeneity of the group’s reading materials, the interests of t... (shrink)

Lethal Autonomous Weapons (LAWs) are robotic weapons systems, primarily of value to the military, that could engage in offensive or defensive actions without human intervention. This paper assesses and engages the current arguments for and against the use of LAWs through the lens of achieving more ethical warfare. Specific interest is given particularly to ethical LAWs, which are artificially intelligent weapons systems that make decisions within the bounds of their ethics-based code. To ensure that a wide, but not exhaustive, survey (...) of the implications of employing such ethical devices to replace humans in warfare is taken into account, this paper will engage on matters related to current scholarship on the rejection or acceptance of LAWs—including contemporary technological shortcomings of LAWs to differentiate between targets and the behavioral and psychological volatility of humans—and current and proposed regulatory infrastructures for developing and using such devices. After careful consideration of these factors, this paper will conclude that only ethical LAWs should be used to replace human involvement in war, and, by extension of their consistent abilities, should remove humans from war until a more formidable discovery is made in conducting ethical warfare. (shrink)

The death of Peter Winch in 1997 sparked a revived interest in his work with this book arguing his work suffered misrepresentation in both recent literature and in contemporary critiques of his writing. Debates in philosophy and sociology about foundational questions of social ontology and methodology often claim to have adequately incorporated and moved beyond Winch's concerns. Re-establishing a Winchian voice, the authors examine how such contentions involve a failure to understand central themes in Winch's writings and that the issues (...) which occupied him in his Idea of a Social Science and its Relation to Philosophy and later papers remain central to social studies. The volume offers a careful reading of the text in alliance with Wittgensteinian insights and alongside a focus on the nature and results of social thought and inquiry. It draws parallels with other movements in the social studies, notably ethnomethodology, to demonstrate how Winch's central claim is both more significant and more difficult to transcend than sociologists and philosophers have hitherto imagined. (shrink)

Background: All research has room for improvement, but authors do not always clearly acknowledge the limitations of their work. In this brief report, we sought to identify the prevalence of limitations statements in the medRxiv COVID-19 SARS-CoV-2 dataset. Methods: We combined automated methods with manual review to analyse manuscripts for the presence, or absence, either of a defined limitations section in the text, or as part of the general discussion. Results: We identified a structured limitations statement in 28% of the (...) manuscripts, and overall 52% contained at least one mention of a study limitation. Over one-third of manuscripts contained none of the terms that might typically be associated with reporting of limitations. Overall our method performed with precision of 0.97 and recall of 0.91. Conclusion: The presence or absence of limitations statements can be identified with reasonable confidence using automated tools. We suggest that it might be beneficial to require a defined, structured statement about study limitations, either as part of the submission process, or clearly delineated within the manuscript. (shrink)

Cultural epistemology: studies in Indonesia.

"[L]ove is not merely a contributor - one among others - to meaningful life. In its own way it may underlie all other forms of meaning....by its very nature love is the principal means by which creatures like us seek affective relations to persons, things, or ideals that have value and importance for us. I. The Look of Love.

Most of the processes subsumed under »digitalization« have in common that they permit switching and simultaneity of sender and recipient roles over a broad range of communications. Preeminently, such communications provide and process information. However, the progress of digitalization in modern lifeworlds is not primarily driven by the development of digital technology. Digital technology is but the appropriate medium for enabling the exchange of the respective formats of information. Its thrust is embedded in a cumulative history of translation of analogue (...) world-relations into such formats of information and, moreover, the progressive transformation of reality in data-structures that can be digitally mapped and controlled. Such structures are attractive because they render our access to and handling of reality more secure and more predictable. Yet they also engender increasing helplessness and discontentment at the boundaries of the digitally controllable world. (shrink)

There is no doubt that custard apple diseases are among the important reasons that destroy the Custard Apple plant and its agricultural crops. This leads to obvious damage to these plants and they become inedible. Discovering these diseases is a good step to provide the appropriate and correct treatment. Determining the treatment with high accuracy depends on the method used to correctly diagnose the disease, expert systems can greatly help in avoiding damage to these plants. The expert system correctly diagnoses (...) Custard Apple disease to make it easier for farmers to find the right treatment based on the appropriate diagnosis. Objectives: A specialized syllable language system was established for the diagnosis of Custard Apple plant disease. (shrink)

In this article, we develop a new approach to integrating philosophical phenomenology with qualitative research. The approach uses phenomenology’s concepts, namely existentials, rather than methods such as the epoché or reductions. We here introduce the approach to both philosophers and qualitative researchers, as we believe that these studies are best conducted through interdisciplinary collaboration. In section 1, we review the debate over phenomenology’s role in qualitative research and argue that qualitative theorists have not taken full advantage of what philosophical phenomenology (...) has to offer, thus motivating the need for new approaches. In section 2, we introduce our alternative approach, which we call Phenomenologically Grounded Qualitative Research (PGQR). Drawing parallels with phenomenology’s applications in the cognitive sciences, we explain how phenomenological grounding can be used to conceptually front-load a qualitative study, establishing an explicit focus on one or more structures of human existence, or of our being in the world. In section 3, we illustrate this approach with an example of a qualitative study carried out by one of the authors: a study of the existential impact of early parental bereavement. In section 4, we clarify the kind of knowledge that phenomenologically grounded studies generate and how it may be integrated with existing approaches. (shrink)

Purpose This paper aims to formalize long-term trajectories of human civilization as a scientific and ethical field of study. The long-term trajectory of human civilization can be defined as the path that human civilization takes during the entire future time period in which human civilization could continue to exist. -/- Design/methodology/approach This paper focuses on four types of trajectories: status quo trajectories, in which human civilization persists in a state broadly similar to its current state into the distant future; catastrophe (...) trajectories, in which one or more events cause significant harm to human civilization; technological transformation trajectories, in which radical technological breakthroughs put human civilization on a fundamentally different course; and astronomical trajectories, in which human civilization expands beyond its home planet and into the accessible portions of the cosmos. -/- Findings Status quo trajectories appear unlikely to persist into the distant future, especially in light of long-term astronomical processes. Several catastrophe, technological transformation and astronomical trajectories appear possible. -/- Originality/value Some current actions may be able to affect the long-term trajectory. Whether these actions should be pursued depends on a mix of empirical and ethical factors. For some ethical frameworks, these actions may be especially important to pursue. (shrink)

We provide an analysis of the public's having warranted epistemic trust in science, that is, the conditions under which the public may be said to have well-placed trust in the scientists as providers of information. We distinguish between basic and enhanced epistemic trust in science and provide necessary conditions for both. We then present the controversy regarding the connection between autism and measles–mumps–rubella vaccination as a case study to illustrate our analysis. The realization of warranted epistemic public trust in science (...) requires various societal conditions, which we briefly introduce in the concluding section. (shrink)

This article explores the enduring mysteries of consciousness and the afterlife, two enigmatic topics that have fascinated humanity for ages. Despite extensive scientific efforts, the existence of an afterlife remains unproven, and understanding consciousness remains a significant challenge. The research introduces innovative hypotheses through simple thought experiments with empirical evidence and robust theoretical foundations. It delves into the complexities of consciousness, its relationship with the brain, and the need for interdisciplinary approaches encompassing physics, psychology, and philosophy. Boldly contemplating the probability (...) of a continuous consciousness after death, the study argues that existing evidence strongly supports this idea. Beyond theoretical implications, it envisions practical outcomes, suggesting that insights into these mysteries could enhance human well-being and contribute to a more harmonious world. In summary, this article embarks on a quest to shed light on age-old questions about consciousness and the afterlife. Through fresh methodologies, it aims to provide new perspectives that could reshape our understanding of existence and inspire intellectuals to positive individual and societal advancements. -/- . (shrink)

Here, I discuss how natural biological evolution might have selected human origin and the psychology of the better mind-brain. However, all humans are closely related; why do we make crimes, war, hate, and jealousy their primary reasons and overcoming methodologies? How can they gain their best happiness? What kind of philosophy apply to annalize this big question and convince humankind to evolve their mind? How we could achieve our optimum potential happiness by developing hidden intelligence to make the world a (...) happier place to live in. (shrink)

How does consciousness vary across the animal kingdom? Are some animals ‘more conscious’ than others? This article presents a multidimensional framework for understanding interspecies variation in states of consciousness. The framework distinguishes five key dimensions of variation: perceptual richness, evaluative richness, integration at a time, integration across time, and self-consciousness. For each dimension, existing experiments that bear on it are reviewed and future experiments are suggested. By assessing a given species against each dimension, we can construct a consciousness profile for (...) that species. On this framework, there is no single scale along which species can be ranked as more or less conscious. Rather, each species has its own distinctive consciousness profile. (shrink)

A review of Personhood, Ethics, and Animal Cognition: Situating Animals in Hare’s Two-Level Utilitarianism, by Gary E. Varner. New York, NY: Oxford University Press, 2012. Pp. xv + 336. H/b £40.23. and The Philosophy of Animal Minds, edited by Robert W. Lurz. New York, NY: Cambridge University Press, 2009. Pp. 320. P/b £20.21.

I examine the epistemic import of collaborative research in science. I develop and defend a functional explanation for its growing importance. Collaborative research is becoming more popular in the natural sciences, and to a lesser degree in the social sciences, because contemporary research in these fields frequently requires access to abundant resources, for which there is great competition. Scientists involved in collaborative research have been very successful in accessing these resources, which has in turn enabled them to realize the epistemic (...) goals of science more effectively than other scientists, thus creating a research environment in which collaboration is now the norm. (shrink)

The dominant framework for addressing procreative ethics has revolved around the notion of harm, largely due to Derek Parfit’s famous non-identity problem. Focusing exclusively on the question of harm treats what procreators owe their offspring as akin to what they would owe strangers (if they owe them anything at all). Procreators, however, usually expect (and are expected) to parent the persons they create, so we cannot understand what procreators owe their offspring without also appealing to their role as prospective parents. (...) I argue that prospective parents can wrong their future children just by failing to act well in their role as parents, whether or not their offspring are ultimately harmed or benefitted by their creation. Their obligations as prospective parents bear on the motivations behind their reproductive choices, including the choice to select for some genetic trait in their offspring. Even when procreators’ motivations aren’t malicious, or purely selfish, they can still fail to recognize and act for the end of the parental role. Procreators can wrong their offspring by selecting for some genetic trait, then, when doing so would violate their obligations as prospective parents, or when their motivation for doing so is antithetical to the end of the parental role. (shrink)

Many accounts of the morality of abortion assume that early fetuses must all have or lack moral status in virtue of developmental features that they share. Our actual attitudes toward early fetuses don’t reflect this all-or-nothing assumption: early fetuses can elicit feelings of joy, love, indifference, or distress. If we start with the assumption that our attitudes toward fetuses reflect a real difference in their moral status, then we need an account of fetal moral status that can explain that difference. (...) I argue that we can have or lack relational obligations to early fetuses in light of our own activities or choices, independent of the fetus’s own features or properties. Those relational obligations make the early fetus morally considerable to the persons who stand in a moral relation to it. Pregnant persons (and other participants in the procreative process) can come to have relational obligations to an early fetus just in virtue of their own decision to create a person, either by intentionally getting pregnant or by deciding to continue a pregnancy. That decision not only makes it appropriate for them to care about the fetus, but it also generates obligations to the fetus that they didn’t have before that decision. (shrink)

The idea that there could be spatially extended mereological simples has recently been defended by a number of metaphysicians (Markosian 1998, 2004; Simons 2004; Parsons (2000) also takes the idea seriously). Peter Simons (2004) goes further, arguing not only that spatially extended mereological simples (henceforth just extended simples) are possible, but that it is more plausible that our world is composed of such simples, than that it is composed of either point-sized simples, or of atomless gunk. The difficulty for these (...) views lies in explaining why it is that the various sub-volumes of space occupied by such simples, are not occupied by proper parts of those simples. Intuitively at least, many of us find compelling the idea that spatially extended objects have proper parts at every sub-volume of the region they occupy. It seems that the defender of extended simples must reject a seemingly plausible claim, what Simons calls the geometric correspondence principle (GCP): that any (spatially) extended object has parts that correspond to the parts of the region that it occupies (Simons 2004: 371). We disagree. We think that GCP is a plausible principle. We also think it is plausible that our world is composed of extended simples. We reconcile these two notions by two means. On the one hand we pay closer attention to the physics of our world. On the other hand, we consider what happens when our concept of something—in this case space—contains elements not all of which are realized in anything, but instead key components are realized in different features of the world. (shrink)

Unter den 12 Jüngern Jesu waren vier Fischer, und als Jesus sie zum ersten Mal sah, waren sie dabei, ihre Netze zu pflegen, zu waschen und zu flicken. Mit seinem Satz, sie sollten ihm folgen, denn er wolle sie zu Menschenfischern machen, verbindet Jesus die bisherige Tätigkeit der Fischer mit ihrem zukünftigen Leben als Jünger und Apostel, als Kern der jungen Christengemeinde. Das Netz der Fischer ist dabei weniger ein Gleichnis für ein Werkzeug, mit dem man Fische überlisten kann um (...) sie zu fangen und zu verspeisen, das Netz hält etwas zusammen, wenn es denn gepflegt und an schwachen Stellen immer wieder geflickt wird. Das Netz ist etwas, das unter der Benutzung verschleißt, und es muss, in Stunden der Ruhe, gepflegt werden. Wenn wir heute vom Vernetzt- Sein sprechen und sagen, dass wir unser Netzwerk pflegen müssen, wenn wir uns fragen, ob wir vernetzt sind oder uns verheddert haben, dann meinen wir etwas ganz anderes, als das, was mit dem Fischernetz im Evangelium angesprochen ist. Ich möchte diesen Unterschied deutlich machen und zeigen, dass das Vernetzt-Sein wie es uns heute im Internet, aber auch außerhalb der so genannten Sozialen Medien oder sozialen Netzwerke, begegnet, eben keine notwendige Lebensbedingung des Menschen ist, dass wir nicht etwa schon immer das Streben nach Vernetzung in uns getragen haben, jedenfalls nicht in der Form, wie wir es heute im Internet betreiben. (shrink)

Der Aufsatz untersucht entlang der Metaphern des Gedichts "Vom Besteigen hoher Berge" die Motivationen und Konflikte von "Gesellschaftlichem Fortschritt", Zielsetzungen und Kooperationen in verschiedenen Gesellschaften.

Objective: Lung cancer is the most common cause of morbidity and mortality. Platinum-based chemotherapy, which is the primary line of treatment, offers limited benefit due to drug resistance and side effects. Berberine (BBR), which is characterised by its potent and safe anticancer activity, represents a promising combination option in chemotherapy. To overcome the limitations in lung cancer chemotherapy, we investigated whether BBR and cisplatin (CIS) exert synergistic effects on non-small cell lung cancer cell line (A549) based on cytotoxicity and apoptotic (...) response markers. -/- Methods: The potential cytotoxic effects of the combination treatment were evaluated using the MTT and Chou-Talalay methods. Elisa assays were also performed to measure the levels of the pro-apoptotic protein Bax and the effector protein caspase (Cas)-3. -/- Results: The results showed that BBR alone reduced A549 cell viability in a dose-dependent manner and synergized with CIS (CI =0.34±0.05 at IC50 concentrations). Elisa results showed that the combined treatment (both at IC50 concentrations) modulated apoptotic signalling pathways in A549 cells. Bax and Cas3 protein levels were dramatically enhanced in A549 cells treated with CIS +BBR compared to control (0.5% DMSO) (p < 0.001). -/- Conclusion: Our results suggest that BBR can synergistically enhance the therapeutic effect of CIS in A549 cells. The potential therapeutic efficacy of BBR as part of a combination in current chemotherapy should be supported by in-depth research and clinical studies on the molecular mechanisms associated with cancer. (shrink)

The Aristotelian view that the moral virtues–the virtues of character informed by practical wisdom–are essential to an individual's happiness, and are thus in an individual's self-interest, has been little discussed outside of purely scholarly contexts. With a few exceptions, contemporary philosophers have tended to be suspicious of Aristotle's claims about human nature and the nature of rationality and happiness. But recent scholarship has offered an interpretation of the basic elements of Aristotle's views of human nature and happiness, and of reason (...) and virtue, that brings them more into line with common-sense thinking and with contemporary philosophical and empirical psychology. This makes it fruitful to reexamine the question of the role of virtue in self-interest. (shrink)

David Hull accounts for the success of science in terms of an invisible hand mechanism, arguing that it is difficult to reconcile scientists' self-interestedness or their desire for recognition with traditional philosophical explanations for the success of science. I argue that we have less reason to invoke an invisible hand mechanism to explain the success of science than Hull implies, and that many of the practices and institutions constitutive of science are intentionally designed by scientists with an eye to realizing (...) the very goals that Hull believes need to be explained by reference to an invisible hand mechanism. Thus, I reduce the scope of Hull's invisible hand explanation and supplement it by appealing to a hidden hand explanation. (shrink)

We reflect on a decade of Responsible Research and Innovation (RRI) as a discourse emerging from the European Commission (EC) 10 years ago. We discuss the foundations for RRI, its emergence during the Seventh Framework programme and its subsequent evolution during Horizon 2020. We discuss how an original vision for RRI became framed around five so-called ‘keys’: gender, open access, science communication, ethics and public engagement. We consider the prospects for RRI within the context of the EC’s Open Science agenda (...) and Horizon Europe programme, before closing with some reflections on the contribution RRI has made to debates concerning the relationship between science, innovation and society over the last decade. (shrink)

This chapter identifies and explores a series of challenges raised by the clinical concept of delusion for theories which conceive autonomy as an agency rather than a status concept. The first challenge is to address the autonomy-impairing nature of delusions consistently with their role as grounds for full legal and ethical excuse, on the one hand, and psychopathological significance as key symptoms of psychoses, on the other. The second challenge is to take into account the full logical range of delusions, (...) which may take the form of true or false factual beliefs, positive or negative evaluations, as well as the paradoxical delusion of mental illness. The third and final challenge is to make room for non-pathological or, autonomy-preserving delusions and to offer a credible way of distinguishing between these and pathological or, autonomy-impairing delusions. By setting out these challenges, we are able to, firstly, distinguish between two separate conceptions of objectivity that may be at work in existing accounts of delusions and, secondly, to put a spotlight on an elusive yet inescapable notion of agential success that underlies our thinking about autonomy as well as mental disorder. (shrink)

There has been a growing interest in research concerning memory modification technologies (MMTs) in recent years. Neuroscientists and psychologists are beginning to explore the prospect of controllable and intentional modification of human memory. One of the technologies with the greatest potential to this end is optogenetics—an invasive neuromodulation technique involving the use of light to control the activity of individual brain cells. It has recently shown the potential to modify specific long-term memories in animal models in ways not yet possible (...) with other MMTs. As the therapeutic potential of optogenetics has already prompted approval of the first human trials, it is especially important and timely to consider the opportunities and dangers this technology may entail. In this article, we focus on possible consequences of optogenetics as an MMT by analyzing fundamental threats potentially associated with memory modifications: the potential disruption of personality and authenticity. (shrink)

Optogenetics is an invasive neuromodulation technology involving the use of light to control the activity of individual neurons. Even though optogenetics is a relatively new neuromodulation tool whose various implications have not yet been scrutinized, it has already been approved for its first clinical trials in humans. As optogenetics is being intensively investigated in animal models with the aim of developing novel brain stimulation treatments for various neurological and psychiatric disorders, it appears crucial to consider both the opportunities and dangers (...) such therapies may offer. In this review, we focus on the memory-modifying potential of optogenetics, investigating what it is capable of and how it differs from other memory modification technologies. We then outline the safety challenges that need to be addressed before optogenetics can be used in humans. Finally, we re-examine crucial neuroethical concerns expressed in regard to other MMTs in the light of optogenetics and address those that appear to be unique to the memory-modifying potential of optogenetic technology. (shrink)